Please, don't ever put yourself in the position of having a margin call happen. If that happens to you, you're not trading in a safe way. Never use more than 50% of available margin. (That number is probably high, too.)
In the current market conditions, I recommend Buy-Writes on the best growth stocks (e.g. MELI, PLTR, and SE, or CDNA and ONDS if you want to take on some more risk, or SOFI and STNE if you want still more risk), or buying LEAPS calls that expire in Jan 2024. I only recommend short puts occasionally, when there's strong evidence that a particular (fundamentally strong and not severely overvalued) security is highly unlikely to drop below an already very low price level.
You don't run the tests...Wanna know how I know?
Because first you have to purify the RNA then run an RT reaction, then purify and amplify the cDNA (you can do RT-QPCR in one step with supermixes but you still need to purify the RNA). There is no pineapple juice or interfering substances by the time you get to the RT step.
AMD has two architectures (as does Nvidia). MI200 is CDNA and they are mainly designed for compute (scientific calculations and ML/AI). While their other architecture is called RDNA. Tencent recently announce they are using V620 which are RDNA based GPU for their server farms.
You can use RDNA for compute and I suppose CDNA for graphics, but they are better suited for their intended tasks.
CDNA sold off like a ma fucka after barely missing earnings. What am I missing? Down 39% since Jan
There server market is about to explode I. Growth with their cDNA architecture and release of their new server proc.
CDNA just dropped 30% on a DOJ investigation. You can always hope for the investigation to turn up nothing.
Well lots more than Ryzen only. Datacenters cDNA 2 coming, Exascale supercomputer due this year first of two wins of 3 the Dep of Energy has awarded to use AMD's chips,... then we have Samsung launching AMD's Exynos in a big way this year. .a lot is going on. .then Xilinx's merger with new TAMs coming. .etc...
Right on! What are some picks that have you interested?
There is nothing better IMO than a company that is actively making the world a better place. Check out $CDNA if you have some time. Biotech that I bought into sub $20. They developed a way to monitor transplant hearts via blood test instead of open heart surgery. How cool is that?! They are moving on to kidneys as well!
Check out $CDNA. Talk about a company with products that materially affect quality of life for transplant patients. Used to just be heart transplant monitoring, but they have recently developed/expanded into kidney monitoring as well. Incredible company. Constantly beating earnings and expectations.
AMD launched their Monster 'Instinct MI100 32GB CDNA GPU' just before Q1, so I'm thinking they specifically wanted to highlight their Datacenter sales this quarter, I'm hoping they finally break down Datacenter sales for EPYC and Instinct into their own categories on their Q1 report, everyone has been asking for it, now might be the time.
Appreciate your .02. I really like CDNA as well, and ur right can’t really compare Illumina and Guardant. Back on CDNA though, I love what the company is doing - and being a recent transplant donor myself, I feel a bit of an attachment lol. Something is in the air though, a buyout makes sense. Saw Ark pulled away though, that gave me some pause. I see them as a great buying opp either way.
I interviewed there a few years ago when they were just $40/share. Not a bad company and a lot to look forward too. I wouldn’t compare it to illumina though as that is a whole other animal. (Illumina basically created the liquid biopsy space with their sequencers, running PCR out the door.) But the two founders are ex-Illumina through another buyout so I was hopeful for one here.
It’s a good steady company, but at 15b for diagnostic products, I don’t know how far it can go without some serious pharma partnership or CDx indications. I do prefer CDNA at their price and growth prospects. A buyout at 2-3x current market cap is possible.
holy wall of text. here's some formatting for ya
Fund Date Direction Ticker CUSIP Company Shares % of ETF
- 1 ARKF 02/24/2021 Buy DSYSJ S2192Y109 DISCOVERY LTD 311,846 0.0667
- 2 ARKF 02/24/2021 Buy FB 30303M102 FACEBOOK INC 27,456 0.1510
- 3 ARKF 02/24/2021 Buy OPEN 683712103 OPENDOOR TECHNOLOGIES INC 120,800 0.0735
- 4 ARKF 02/24/2021 Buy SQ 852234103 SQUARE INC 97,051 0.4928
- 5 ARKF 02/24/2021 Sell VRSK 92345Y106 VERISK ANALYTICS INC 135,953 0.4859
- 6 ARKF 02/24/2021 Sell TCEHY 88032Q109 TENCENT HOLDINGS LTD 70,287 0.1322
- 7 ARKF 02/24/2021 Sell LSPD 53227R106 LIGHTSPEED POS INC 130,200 0.2028
- 8 ARKG 02/24/2021 Buy ACCD 00437E102 ACCOLADE INC 62,178 0.0249
- 9 ARKG 02/24/2021 Buy CMLF 18978W109 CM LIFE SCIENCES INC 187,400 0.0333
- 10 ARKG 02/24/2021 Buy SGFY 82671G100 SIGNIFY HEALTH INC 295,500 0.0939
- 11 ARKG 02/24/2021 Buy MASS 65443P102 908 DEVICES INC 9,223 0.0048
- 12 ARKG 02/24/2021 Buy RPTX 760273102 REPARE THERAPEUTICS INC 13,842 0.0040
- 13 ARKG 02/24/2021 Sell TWST 90184D100 TWIST BIOSCIENCE CORP 104,449 0.1278
- 14 ARKG 02/24/2021 Sell HIMS 433000106 HIMS & HERS HEALTH INC 168,557 0.0240
- 15 ARKG 02/24/2021 Sell CDNA 14167L103 CAREDX INC 99,611 0.0692
- 16 ARKK 02/24/2021 Buy TXG 88025U109 10X GENOMICS INC 15,458 0.0109
- 17 ARKK 02/24/2021 Buy SQ 852234103 SQUARE INC 534,390 0.5076
- 18 ARKK 02/24/2021 Buy BEAM 07373V105 BEAM THERAPEUTICS INC 190,834 0.0724
- 19 ARKK 02/24/2021 Sell SNAP 83304A106 SNAP INC 1,205,432 0.3333
- 20 ARKK 02/24/2021 Sell TCEHY 88032Q109 TENCENT HOLDINGS LTD 221,971 0.0776
- 21 ARKQ 02/24/2021 Buy WKHS 98138J206 WORKHORSE GROUP INC 660,500 0.2456
- 22 ARKQ 02/24/2021 Buy VUZI 92921W300 VUZIX CORP 307,163 0.1530
- 23 ARKQ 02/24/2021 Buy RAVN 754212108 RAVEN INDUSTRIES INC 404 0.0004
- 24 ARKQ 02/24/2021 Buy EXPC 30217C109 EXPERIENCE INVESTMENT CORP 94,994 0.0395
- 25 ARKQ 02/24/2021 Buy AONE G7000X105 ONE 208,917 0.0640
- 26 ARKQ 02/24/2021 Sell FLIR 302445101 FLIR SYSTEMS INC 23,918 0.0333
- 27 ARKQ 02/24/2021 Sell DE 244199105 DEERE & CO 17,463 0.1527
- 28 ARKQ 02/24/2021 Sell CAT 149123101 CATERPILLAR INC 25,764 0.1453
- 29 ARKW 02/24/2021 Buy SQ 852234103 SQUARE INC 165,829 0.4557
- 30 ARKW 02/24/2021 Sell SNAP 83304A106 SNAP INC 310,043 0.2449
By AMD's roadmap, they will release Zen 4 later this year. Supposedly on TSMC 5nm.
Yesterday the rumor was circulated that their Genoa Zen 4 server processor will have a +29% performace boost compared to their current Milan Zen 3 server processor.
Of course those are just rumors, but that's also a huge generational improvement, again.
And before Zen 4 there will be a Zen 3+ this year, combined with the releasse of the AM5 socket and DDR5 support. And there's going to be RDNA 3 and CDNA 2 this year. AMD is going to have another big year.
You want some clear 2021+ winners? BNGO > TWST > PACB > CDNA.
Throw in some PLTR for diversification.
I work with these technologies on a daily basis and I can say that CDNA is not going to be enough. AMD might compete in that segment at some point but that can't possibly happen until at least 2025. I don't think AMD is after that segment right now anyway
They're leading AI, for now... next gen CDNA is going to be a game changer.
TWST, TDOC, CDNA, IOVA, EXAS, FATE are all down dude.
Lol I put in a sell order for my CDNA call and it immediately dropped 1%
There is no announcement. It just my personal assessment of the scientific data. BioNTech uses an engineered RNA sequence to maximize protein production and drive immune response. this reduces costs but could have side effects if the engineered sequence has off target effects. Moderna uses a natural mRNA sequence to increase protein production (assumed based on their patents) and randomizes the cDNA sequence so the vaccine mRNA is less likely to combine with the virus. They both are safe and effective short-term. What I'm saying isn't a currently proven risk, but if I had to choose between these two amazing feats of science, I'd go with moderna.
PACB down 16%, CRSP down 10%, TWST down 12%, TDOC down 1%, ARCT down 54%, CDNA down 6%, NVTA down 6%, PSNL down 12%, IOVA down 5%, EXAS down 3%.
Those ten stocks account for over 45% of their holdings.
ARKG isn’t just CRSP. It’s portfolio of companies that will reshape healthcare products n the next 5-10 years. You also have companies like PSNL, CDNA, ARCT
Queen Cathie went on a motherfucking shopping spree today holy shit.
ARKF 2020-12-21 Buy AMZN
ARKF 2020-12-21 Buy BABA
ARKF 2020-12-21 Buy JD
ARKF 2020-12-21 Buy KSPILI
ARKF 2020-12-21 Buy NVDA
ARKF 2020-12-21 Sell TRU
ARKF 2020-12-21 Sell SQ
ARKF 2020-12-21 Sell IBKR
ARKG 2020-12-21 Buy REGN
ARKG 2020-12-21 Buy LGVW
ARKG 2020-12-21 Buy IONS
ARKG 2020-12-21 Buy GOOGL
ARKG 2020-12-21 Buy EXAS
ARKG 2020-12-21 Buy CDXS
ARKG 2020-12-21 Buy VRTX
ARKG 2020-12-21 Buy BLI
ARKG 2020-12-21 Buy RHHBY
ARKG 2020-12-21 Sell TWST
ARKG 2020-12-21 Sell VCYT
ARKG 2020-12-21 Sell EDIT
ARKG 2020-12-21 Sell CRSP
ARKG 2020-12-21 Sell CDNA
ARKK 2020-12-21 Buy U
ARKK 2020-12-21 Sell XONE
ARKQ 2020-12-21 Buy KMTUY
ARKQ 2020-12-21 Buy FLIR
ARKQ 2020-12-21 Buy BIDU
ARKQ 2020-12-21 Sell MTLS
ARKQ 2020-12-21 Sell XLNX
ARKW 2020-12-21 Buy SHOP
ARKW 2020-12-21 Buy NVDA
ARKW 2020-12-21 Buy BABA
ARKW 2020-12-21 Buy ADBE
ARKW 2020-12-21 Buy AAPL
ARKW 2020-12-21 Sell PD
ARKW 2020-12-21 Sell ROKU
ARKW 2020-12-21 Sell SPOT
ARKW 2020-12-21 Sell SQ
ARKW 2020-12-21 Sell TWLO
ARKW 2020-12-21 Sell WORK
It's not the only one that's gangbusters
PACB, NVTA, TWST, PSNL, FATE, CDNA, IOVA
someone mentioned CDNA on the Tuesday daily thread, thank you! 🥳🤗🖖
ABBV, CDNA, and VERU calls. Thank me in a week.
CDNA CLLS both went up decently recently also NVTA is nice
Does anyone else have any cdna puts? That stock has been far to green in my opinion. I could just be an idiot idk
This is anecdotal but two stocks that I've dealt with were big winners and I don't recall seeing talk about them on Reddit. In fact sometimes the opposite.
NIO and CDNA. Dealing with them when they were both $1 or so.
Anyone else holding any CDNA puts? They're pretty cheap right now at a 52 week high
Yeah, i think ppl are applying value to AMD from Ampere and new hype, but i think its more than offset by the CDNA architecture being a (likely underperforming) rival to Ampere.
AMD launching big Navi (RDNA2) and CDNA data center GPUs in next few months
That's the second one.
First one was CDNA.
My life just consists of getting fucked by not having fun money and I don't even have enough money to shitpost here.
Meanwhile if you look at AMD’s pipeline, they have 7nm and 5nm tech in the works, while Nvidia has just planned on releasing 7nm in Ampere.
AMD Epyc processors trumps Nvidia’s server chips and thus AMD is ahead on the Cloud game
AMD is in Xbox and Playstation, set to release Q4
Even though Apple divorced with Intel, but they will still continue to use AMD to provide GPU for their MBP and Mac line.
While Nvidia is ahead in Cuda, AMD has already started on CDNA to compete against Cuda.
AMD still has loads to give. Just my 2 cents.
Verizon is expensive, but I see you also went balls deep on an expensive phone. I usually buy my phones outright and I go middle of the road so they're not cutting edge but also not bottom of the barrel cheap. I prefer vanilla Android and hate all the changes and bloat that different manufacturers add. My past phone progression with price paid has been(from current to older):
Motorola X4 Android One Edition financed through Google Fi 0% interest across 24 months(last payment is next month) on sale for <$250(retailed for $399 at the time) so monthly payment of $10.38
Nexus 5X(LG/Google) financed through Google Fi 0% interest across 24 months on sale for $399(was $449 retail at the time, larger storage option) so monthly payment was $16.67/month for 24 months.
Nexus 4(LG/Google) bought outright for $399
In regard to service, I used to have T-Mobile and used to pay $50/month for unlimited talk text and data. I moved from the East Coast back to the Mid West in 2013 and found that T-Mobile had great service near my work, but horrible service near my house. That was right when Google Fi(known at the time as Project Fi) opened up for beta sign up. I got on the waiting list and got my invite 3 months later. I love Fi because they support both CDNA and GSM networks and leased their tower usage from T-Mobile and Sprint among others. They automatically connect you to the stronger signal so suddenly I had great reception and data speeds everywhere I went. It also supports WiFi calling so I can even make calls in my basement. Lastly the best part for me is that I never use much data as I'm on WiFi almost everywhere I go. They've changed pricing of data a few times over the years but it's always been exactly $10 per GB. And they don't round, so if you use 1 GB and 628 MB your data bill for that month is $16.28 added to your talk and text(which is only $20 per month). So, in that scenario my monthly bill with my $10.38 phone charge would've only been $46.66 which isn't bad considering the phone financing in there as well. Lastly, they now no longer charge for over 6GB per month and from 6GB-22GB there isn't a fee. Once you hit 22GB they will throttle you unless you agree to pay $10 per GB again for un-throttled data. That's pretty much the same as most carrier's unlimited plans($20 for talk/text + $60 data(unlimited but throttled after 22GB for a total of $80/month).
For me personally this plan is great because I average less than 200-500 MB per month since I'm always on WiFi at both home and work(before I got laid off last week) so my bill with phone financing has been usually right around $35/month, and after next months bill that pays off my phone my bill will drop to around $25/month until I decide to get a new phone(I average once every 3-4 years on a phone).
Those PE guys have missed the train. AMD is a growth company with <20% CPU share in desktop & notebook and 5% in data center. Intel has literally no growth for few years and revenue may compress overtime. AMD is backed up by superior TSMC process along with superior architecture on all three platforms datacenter, desktop and mobile.
NVDA had literally no competition from AMD in the last five years in the high end and ultra high end market especially in the notebook and data center market but that may about to change soon as AMD will be launching RDNA2 GPUs for gaming and CDNA for data center (high end GPUs). NVDAs revenue will feel the impact of increased competition.
You start with pennies. Spreadsheet ratings from every possible source, then watch the chart for a proper dip. This is an example of their trades for a few days...
CLLS APT IMRA DMAC GRWG EDNT WIX CBLI OPK ALO IBIO GROW NVMI AEYE AXU GERN CVM BLU NLS SMG FLAT EVSI TPTX NVDA ICLK LGC RPAY ARYA MMX JD NOW KMED KURE CCX LCA HYAC RWLS OCX DBP GLTR HARP LCR AMZN AGMH IBMP SUMR REPL FUMB CCH IBML OFLX SUB IBMK FLMB HCAC BSCS SMB UUP MFAC LSST SMMU RAVI VNLA JMST LINC WBC TZAC ARYAU BSCR GRAF SPAQ YI BTAL REK COLL KOPN PCYG AUPH WTRH UI DPZ IMKTA SFM MRTX AGTC VTVT HAIN AZRE DDOG MARK PEP FB ZNGA HL V NET LOW ZM XBI ATVI CPB HMY Z SVM IIVI LABU NEWR XLC NGD WPM CHD ROK CNAT ASM ADSW ADBE CLX IGV GOOGL IMGN VRTX QLD GOOG WBC FLO STE THO FTNT OCUL EE OR ILMN MRNS NTLA CRSP MASI ENTG PAYC WGO SHW INSM AGFS LTRX MTUM EDIT ITCI CORT KURA NBIX GNRC CALM VGT LIVX CRNC PULM AOBC BL ZG NOVA CDNA CDAY TYL ARCT SPSC GOLF OCFT SWAV UUP ARKG HZO RMD TYME ICLK COLL BIB VERU GWPH AAAU AVEO BGNE TMQ INSP PFSW BCEL ASMB FTEC LOCO AVAV CSGP CHE DMAC GROW CRTX IMXI SUB CSTL YMAB EVOK ARGX CRNX FENC RLMD PDP KNSL NLTX ESPO GRAF CIIC APPF IYW CMF CHG ANY WEBL PRSC MOR ROM QMOM IGMS ENG XPH VTIQU PTNR ARYA CSBR STSA AGZ ARDS CPAH SBIO FULC PHAT ETHG ETNB IBMJ IBML CNCR DBS XNTK IETC XSW LIVE BIOX GTO DGL PSJ GNOM MOM MFMS MIRM ACAM PBE BMAY DFND AIQ GUDB PLL HTAB BKAG CCX CIZN SMMC SPSK LCA BKSB AAMC AMCI SBUG COFS MTGP GBUG NFINU FLAT
I mean.. not to be a dick but unless you recommended SHOP TTD DXCM AMD MDB CDNA NVDA DOCU. I would say you gave pretty mainstream recs, perhaps SQ being the exception.
Give it few months. Its going to come down. Their revenue is still below 2018 peak. This is when they have zero competition in the high end gaming market and little competition in the data center space for last 5 years. This is going to change later this year when AMD launches RDNA2 GPUs for gaming and CDNA for data center.
Why would they?
They make a shitton of money. Even if RDNA 2 and CDNA 1 from AMD are good, they will still outsell AMD and have higher margins.
Genuinely curious, what makes you think AMD is overvalued? It's the company I'm most bullish on by a very significant margin.
2020 earnings are expected to be quadruple 2019's, which alone would bring the P/E down to a sane-ish level. Guidance is an average yearly revenue growth of 20% for the next 5 years. AMD has always matched or outperformed guidance since Lisa Su took the helm. AMD have stated they guide on the assumption that their competitors stick to their roadmaps - Intel has already gone off course since AMD's investor day with Comet Lake-S 1/2 socket being cancelled, meaning they have nothing in the boarder server market to compete with AMDs 64 cores for not only Zen 2 but also Zen 3. I wouldn't trust Intel's roadmap to not slip further.
AMD just paid off over half their debt. All the major cloud providers (AWS, Azure, Google Cloud) have AMD platforms now. A majority of the recent supercomputers are AMD based. Cloudflare swapped to AMD. Around now-ish we should see AMD hardware starting to get certified for enterprise software. The next consoles are all AMD and they sound swish. Nokia is using AMD for their 5G platform at least in part (not many details on this one but they talked at AMD's investor day).
All of the problems with AMDs mobile platform (high chipset idle draw, no LPDDR) have been rectified with Zen 2 - all the leaks point to Ryzen 4000 mobile trading blows with Intel on perf but at a lower power draw and much lower price.
GPU side is dicier. Lack of CUDA is still an issue. Drivers still aren't reliable enough. Miles behind Nvidia on efficiency. That said, they are still gaining market share from Nvidia. Recent updates have improved drivers dramatically, RDNA has been a massive step forward on the efficiency front, and RDNA2 looks to be a similar step again. Splitting gaming and compute into two different archs (RDNA and CDNA) is exactly the kind of move they should be making.
All serious obstacles as I see them (competitive ARM server chips, Intel chiplet design, viable x86 emulation on ARM) are at least 3 years out.
AMZN - 17%
DIS - 15%
MCD - 10%
VTI - 10%
DIN - 6%
TWTR - 6%
CDNA - 5%
MRVL - 5%
XLNX - 5%
VOOG - 5%
SBUX - 4%
IRM - 3%
SHAK - 3%
SQ - 3%
HD - 3%
CDNA 15 $1.10 on May 8, 2017
ASNA 6 $3.65 & 2 $3.81 May 8 & 9, 2017
Sorry, should specify. Synthetic construct (cDNA) constructs can be patented, native DNA cannot. Since CRISPR/Cas9 is a native protein/proto-immune system occurring in bacteria the IP surrounding it is a bit sketchy (who was the "inventor"). I'm not saying it can't be done, just that I wouldn't hang my hat (or dollar) on it. See the supreme court decision Association for Molecular Pathology et al. v. Myriad Genetics for more information on this, I expect it will be heavily sighted as precedent moving forward in biotechnology.
I'd have her look into her usage habits and see what tiers she'd fall into. If she uses more than 2GB of data a month, Ting may not be the best option.
My BF and I average 1GB a month, <500 min, and <2000 txts, so our bill will typically be $48 a month. If any of those go up a tier, we'll be ~$60.
As for service, its been flawless so far. BF has been using it for 3 months, myself 1 week, and there hasn't been a single issue.
Also note that they have 2 networks available- GSM or CDNA (I think those are right). You'll have to chose one when you sign up.
> Doesn't the legal definition of gene the important part? Even if gene really means nothing to scientists wouldn't what it means to a lawyer be more important in terms of patents.
I suppose that is correct. However, then the headlines proclaiming victory for the lack of patentability of a human 'gene' turn on quite the absurd use of the noun. If the definition of gene in those headlines is the legal one and not the scientific one - and those definitions differ - then there is quite a bit of misconstruction going on.
Regarding the 'methods' patent. The methods for obtaining cDNA have changed (read, imporoved) dramatically in the nearly two decades since Myriad did their thing. It is now doable by a robot. And there are many other ways to extract cDNA now. Most notably with direct sequencing. You just sequence the stuff. You can also work backwards from a protein sequence if you have it. There is so much prior art in this space it would be quite difficult to defend the process of obtaining a cDNA. The only thing Myriad could have claimed was the process of finding this cDNA - but that's quite a narrow reading of the technology - and was struck down by the ruling.
cDNA is not used for most of the genetic tests (it was back in the day, not anymore). A lot of companies like Ambrygen and GeneDX use gDNA(genomic...i.e naturally occurring) to report the mutations. Hence, its a huge victory.
Source: I am a Genetic Counselor.
Edit: My guess is Myraid also uses gDNA, i might be wrong.
theBPPE has a good comment, but it's lacking some science. As a biochemist who is sitting in lab synthesizing some DNA right now behind me, I'll say this:
The ruling is poorly formed. DNA in a human body exists in a kind of obfuscated form for various reasons. When it comes time to actually read it, the body compresses and trims it down to its useful, temporary form (as mRNA). Scientists then copied that mRNA back into DNA. And then patented that DNA.
So there are 3 items up for grabs here:
the method for getting a 'gene' (btw, "gene" is about an antiquated term as 'aether' - it was a placeholder science word that makes no sense and has no solid definition in modern science)
the sequence of DNA found in the body (which is on the order of 10,000-100,000 bases long
the 'cleaned up' sequence of DNA (which is on the order of 1,000 bases long).
The court ruled the method is patentable (but no one cares, as there are many other ways to do it. No one uses or needs Myriad's method).
The court ruled that the natural full-length 'gene' is not patentable (again no one cares, because it's 90% useless. No one ever cares about the actual sequence in the body because it is not a functional unit either for study or for the body).
The court ruled that the cleaned up DNA is patentable. It is technically true that that molecule does not exist in nature. But as others have said the transformation is trivial. But this is the most useful/used form of DNA. In lab I have a freezer full of cDNAs I use in my study of breast cancer. If each of those molecules was patented I'd only be able to afford a very small fraction of them.
ALSO, because the cleaned up form is patented, every time I did some basic experiments I'd likely be infringing on their patents. Though it was a bit tricky at the time (1997), it is now a truly routine thing to pull out these cDNAs. Whole companies exist to trade these molecules.
tldr; 'gene' is a useless word, and 'genes' are not patentable - no one cares. The (natural) cDNA is the functional unit we use in the lab. This was declared patentable. The human sequence for the proteins made naturally in YOUR body was declared patentable. I make hundreds every day in the lab - it's a really weird rendering of the science.
I'm really not sure about the implications of this. Would be interested to hear somebody else who knows more.
It seems to only cover testing and research, since anytime you create a novel molecule (e.g. a drug) it can be patented. If a particular gene were patentable, it would mean that anybody who wanted to test for that gene in any way would need to pay a license fee. It would also mean anybody researching the effects of that gene would need to pay for the privilege. Basically it means you can't patent a gene, but you might be able to patent artificially created products of that gene. And you can't stop other people from researching a gene.
The fact that cDNA is patentable means that tests/research which involve genomic DNA -> mRNA -> cDNA would likely need to pay a license fee. This would cover a lot of research, RNA-seq is a vital research tool and it would be a shame to have it be so constrained.
It also likely means clinical testing can't cut costs by only sequencing an exome instead of the genome. But if you're only looking at a specific genomic region I don't think it's too costly to just sequence the gDNA, so maybe it's not so bad.
I don't know if Myriad holds a patent on the relevant cDNA, my guess would be not. But their patent was expiring next year anyway. So the implications for this company is pretty minimal (unless they hold other gene patents)
Somebody should also tell the supreme court that cDNA is naturally occurring.
Source: I work in genomics, but I'm not a biologist
If you are talking about non-coding regions of the DNA, sure I guess so? To my knowledge those areas of genes are filled with redundant noise and evolutionary artifacts. But coding regions of genes aren't noise. They need to be VERY precise sequences in order to make the functioning proteins. So yes, maybe through some mutations any relatively short segment you can think of will probably be "naturally occurring" in non-coding regions, but in the regions of DNA that actually make proteins (the money regions, basically) any deviation from the natural code could limit the functionality of or even destroy the protein.
cDNA is the complement to mRNA, which is the complement to DNA with all those pesky non-coding regions (called introns) cut out. Essentially, cDNA is the DNA that is only used for making proteins. This DNA is not "naturally occurring" only because DNA usually has a lot of useless pieces in it, and this process takes those out.
>“We hold that a naturally occurring DNA segment is a product of nature and not patent eligible merely because it has been isolated,”
Genuine question, couldn't any DNA segment have the potential to be naturally occurring?
>The court did rule that synthetically created DNA, known as cDNA, can be patented “because it is not naturally occurring,” Thomas said.
What if the synthetically generated DNA is identical to naturally occurring DNA?
All corporations start with an idea, and that idea defines the "corporate DNA" so to speak. That cDNA determines what endeavors the company will be good at, and what it won't. Just look at Cisco as one example. Whenever they've purchased another company that makes networking gear, its turned out more or less pretty good. All their efforts at improving their networking gear go well. But, let them try to make phones or tablets. Suddenly, failure errupts. It's rare for a corporation to step significantly outside their DNA and have it go well. But, at a certain point in their growth line, they also can't really fail. Lots of places have invested in Cisco VoIP infrastructure, yet it's the lesser of the choices out there. It's as though there's a halo effect, and if a company is successful enough, they can sell bags of poo on reputation alone. Case in point is the success of coffee percolators in the fifties. Percolated coffee basically liquid shit you make at home. People were told how great it was, and so the story goes.
Google has been becoming more and more annoying, constantly bugging me to link things without really giving me a practically compelling reason to do so. Link my google account with my youtube account. Why? Why sign into google at all was my first reaction when they started asking me to. I just come here to search, I thought. I do think the innovative google tools and applications are compelling, and I'd use them more if google would just get the hell out of my way, and not bug me so much.
I'm quite annoyed by facebook bugging me too. I don't go there much mostly because I always feel like they're pushing too hard. It's like the difference between the neighbor grocer and Sam's club, the latter of which gives me a headache, and I don't leave feeling better than when I walked in. Google+ is like that, shoving other people's shit in my face. I'm not saying G+ is altogether bad, but its certainly not altogether good. Google should stick with searching, not try to be someone else.