Ashleigh Barreto – Director-Investor Relations and Corporate Communications Greg Went – Chairman and Chief Executive Officer Alf Merriweather – Chief Financial Officer Rajiv Patni – Chief Medical Officer

Josh Schimmer – Evercore ISI David Amsellem – Piper Jaffray Ken Cacciatore – Cowen and Company Ryan Abbe – JMP Securities Irina Koffler – Mizuho John Sullivan – Leerink Partners Ram Selvaraju – H.C. Wainwright Serge Belanger – Needham & Company

Thank you, operator, and good afternoon, everyone. Joining me on the call today are Dr.

Greg Went, our Founder, Chairman and Chief Executive Officer; Alf Merriweather, our Chief Financial Officer and Dr. Rajiv Patni, our Chief Medical Officer.

Before we begin, I’d like to remind everyone that this call will contain forward-looking statements, which are subject to risks and uncertainties. Any statements regarding future events, results or expectations are forward-looking statements.

Please note that these forward-looking statements reflect our opinions only as of the date of this call. We undertake no obligation to revise or update these forward-looking statements in light of new information or future events.

Information concerning factors that could cause actual results to differ materially from those contained in or implied by such forward-looking statements are discussed in greater detail in our Form 10-Q filed with SEC today. I would now like to turn the call over to Greg.

Greg?

Thank you, Ashleigh, and good afternoon, everyone. Thank you for joining us today.

At Adamas, our mission is to work each and every day to meaningfully enhance the daily living experience of those affected by central nervous system disorders. We do this by staying true to our vision to create a world, in which time dependent medicines are the standard of care.

Our commercialization of GOCOVRI, the first and only medicine approved for the treatment of dyskinesia and people with Parkinson’s disease taking levodopa-based therapy, is advancing both our mission and our vision. Our follow-on indications for GOCOVRI, such as our ongoing Phase 3 evaluation in multiple sclerosis walking and pipeline products, like our program epilepsy, are progressing in accordance with our vision.

We created GOCOVRI, a glutamatergic therapy for the treatment of dyskinesia and people with Parkinson’s disease. Importantly, it is also clinically proven to reduce both dyskinesia and OFF.

These reductions result in GOCOVRI widening the therapeutic window for dopaminergic treatments like levodopa. GOCOVRI has taken at bedtime and is the only amantadine to use a time-dependent approach to deliver high levels of medicine when the patient needs it most upon waking in the morning, before the first dose of levodopa and then delivers lower levels during the night.

GOCOVRI represents a paradigm shift in the Parkinson’s disease treatment landscape on multiple levels. It shifts to focus from dopamine to dopamine plus glutamate, from threading the therapeutic window to widening it, from daytime administration to bedtime administration.

Based upon its clinical effect on OFF and dyskinesia, GOCOVRI should be considered the preferred adjunct therapy to levodopa in people with Parkinson’s disease. As we reflect upon the first nine months of GOCOVRI commercializations, we are encouraged by the strong foundation we’ve established and the progress with the launch today.

As Alf will discuss in more detail, we have a solid quarter, with revenue of $10.6 million. We had approximately 4,700 filled and reimbursed scripts in the quarter.

And since making GOCOVRI available, nearly 1,200 unique prescribers. While early, we are very pleased with the persistence, with the significant majority of patients six months from starting on GOCOVRI remaining ON and our compliance to date is outstanding.

Additionally, our market access and distribution are solid. While this is a great start, we have only just began to realize the growth potential of GOCOVRI and we believe we are on our way to reaching our goal of 25% to 30% penetration.

After three quarters of commercialization, we have increased our understanding of market dynamics and we are making adjustments and applying the learnings, which we believe will lead to the prolonged success of GOCOVRI. First, we have long understood that GOCOVRI adoption in major movement disorder centers, which treat a large portion of Parkinson’s patients, is critical to our business.

At this point, we believe that approximately 10% of the major centers have adopted GOCOVRI for greater than 5% of their eligible patients. Adoption is occurring in a combination of amantadine experienced and naïve patients.

We need to continue to expand the use of GOCOVRI in these centers where it has been initially adopted and penetrate additional key treatment centers. To address this, we are refining our execution and focusing our sales efforts on these prescribers.

In addition, we continue to improve and educate on the seamless access experience provided by GOCOVRI onboard to support adoption and shorten times to fill. Second, we must effectively communicate the scientific rationale and clinical benefits of GOCOVRI.

We have learned a great deal from our first nine months on how to effectively message the benefits of GOCOVRI to neurologists and we are simplifying and strengthening it. In addition, we are elevating our education on the glutamate pathway involvement in the Parkinson’s journey as its role is not fully recognized.

For GOCOVRI, neurologists focus solely on threading the dopaminergic therapy through the narrowing therapeutic window as the way to manage these patients. This often led to an under treatment of their underlying Parkinson’s symptoms.

We believe that the potential for GOCOVRI, a glutamatergic time-dependent therapy, is to open the therapeutic window, and that’s significant. And we can move that walking center in physician’s mind for better training and education.

Thirdly, the initial use of GOCOVRI by neurologists has focused on Parkinson’s disease patients experiencing more severe dyskinesia. This contrasts with the broader segment of the patients we studied in our clinical programs.

Just to address this, we are targeting patients across the full spectrum of dyskinesia in severity and duration, including those who have just started experiencing dyskinesia. We are using tools like patient profiles to help prescribers identify appropriate patients based upon the scope of our clinical program.

Additionally, we are refining our communications regarding appropriate dosing to help prescribers use GOCOVRI. Dosing can directly impact prescriber and patient experience with the medicine.

For example, patients with moderate-to-severe renal impairment, which can occur more often in the elderly, should start GOCOVRI at the 68.5 milligram dose to balance the efficacy with the tolerability per GOCOVRI’s label. So to summarize, we are driving increased adoption in three ways: by refining our sales execution by focusing on MDS centers and high-potential prescribers; by simplifying and strengthening our messaging for GOCOVRI as a treatment for dyskinesia as well as its benefits in OFF, highlighting the role GOCOVRI plays in widening the therapeutic window for dopamine treatments; and effectively educating physicians on appropriate use and appropriate patients for GOCOVRI.

We are well on our way to establishing GOCOVRI is a standard of care for people with Parkinson’s disease with dyskinesia, and we understand the changing prescribing behavior and driving use of first-to-market medicines takes time. We continue to believe that GOCOVRI is an extremely important drug and that we can reach 25% to 30% peak penetration in the Parkinson’s disease dyskinesia population and then build greater value with additional indications.

Finally, I am very happy with our dedicated and committed organization, our U.S. footprint and we’ll continue to strengthen and deepen that team over time.

Over to you, Alf.

Thanks, Greg, and thank you all for joining our call today. In addition to discussing our third quarter results, based on Greg’s commercial commentary, I will provide our thoughts on the outlook for the rest of 2018 and 2019.

We recorded GOCOVRI product sales in the amount of $10.6 million for the third quarter and $20.7 million for the nine months year-to-date. This was recorded on the sell-in method, with revenue recognized typically upon delivery to our specialty pharmacy.

For the quarter, the total number of paid prescriptions dispensed to patients was approximately 4,740 compared to 3,430 in the second quarter. This number does not include drug provided no charge to the patient through Quick Start and other patient assistance programs.

Also as of September 30, the total number of prescribers has increased to approximately 1,200 from 970 at June 30. Due to patient starts having been at generally consistent level over the last two quarters, we are intensely focused on increasing demand, especially as Greg noted at movement disorder centers over the next several quarters.

Total paid prescriptions were strong in the quarter, reflecting good persistence and compliance levels for patients on drug. A year ago, we suggested that for a launch such as ours in the CNS space, a reasonable expectation for first year average penetration of the target patient population would be about 1%.

For the full year of 2018, we expect our results to be consistent with that framework. Looking at 2019, we similarly believe that approximately 2% market penetration on average for the year isn’t appropriate framework.

Gross net adjustments or GTN for the third quarter were generally consistent from the second quarter and our expectation is that this will continue in the fourth quarter. Looking to 2019, our expectation is the GTN will overall be in the high teens to low-20s as a percentage.

This is higher than 2018 due to changes for 2019 in the Part D rules that will require manufacturers to bear a greater portion of cost during the doughnut hole period. This change may also mean that the doughnut hole will impact Q2 as well as Q1 in 2019.

We continue to believe that our previously stated range of expectations for GTN and the 25% to 35% is an appropriate long-term framework. With regard to our financials, research and development expenses were $11.7 million during the third quarter reflecting continued enrollment in the ongoing phase 3 trial for ADS-5102 and multiple sclerosis walking and preparations for pivotal studies for ADS-4101 in epilepsy that we expect to start in 2019.

With respect to selling, general and administrative expenses, these are $27.5 million for the third quarter, consistent with the prior quarter. Interest expense was $5.4 million for the quarter.

This reflects interest accrued based on an estimated effective interest rate, not the nominal coupon rate or royalty rate reflected in our royalty-backed debt agreement. Regarding our overall operating results, net loss for the quarter was $33.2 million or $1.22 per share; in both cases, slightly reduced from the prior quarter.

Cash used in operations for the quarter was $23.2 million, lower than the $32.6 million in the second quarter. Cash and investments as of September 30 were $233 million positioning us well to execute on the key programs in [indiscernible].

I’ll now pass the call to Rajiv.

Thanks, Alf. Good afternoon.

I would like to start by reminding everyone that aberrant glutamate signaling is a key mechanism that underlies the occurrence of both dyskinesia and OFF. GOCOVRI’s proven benefits on both the hyper- and hypokinetic symptoms is how it uniquely widens the therapeutic window.

Also, the treatment effect of GOCOVRI was demonstrated without changes to levodopa dose. It represents, in our view, a game changer for the treatment of Parkinson’s patients, who have begun to experience dyskinesia and OFF.

I would like to make another crucial point. GOCOVRI represents to date our strongest example of a time-dependent medicine and approach that maps and matches drug levels to the time when they are needed most.

It is noteworthy that we administered the full daily recommended dose of GOCOVRI, 274 milligrams, as a single dose at bedtime with an acceptable tolerability profile. This has never been done with any other form of amantadine.

Moving to Hong Kong. The 22nd International Congress of Parkinson’s Disease and Movement Disorders was an opportunity for us to present our final open-label Phase 3 data and continue our disease education efforts.

On the Phase 3 data, we reported a 35% treatment effect with GOCOVRI on both dyskinesia and OFF. This large treatment effect was observed at week eight and was maintained up to week 100.

Moreover, this treatment effect was consistent in all subgroups, including patients, who are still experiencing dyskinesia at baseline despite treatment with amantadine immediate release. Discontinuations over the 100-week period were mostly due to reasons that were not related to adverse drug reactions, which is to be expected given the steady population and steady duration.

We also provided disease education at our very well-attended medical booth at this meeting. We focused on the role of glutamate in both dyskinesia and OFF as well as our data on the diurnal patterns of dyskinesia and OFF with an emphasis on transitions during a waking day.

The term transition captures the number of times during the waking day that a patient goes from being ON to being either OFF or dyskinetic. This concept is a logical extension of the therapeutic window, which is narrowed on the top by dyskinesia and narrowed on the bottom by OFF.

We have also progressed our evaluation of additional indications for GOCOVRI. For instance, there may be an opportunity to expand the GOCOVRI label in Parkinson’s disease as well as in certain pediatric movement disorders.

We will make a final decision in first quarter 2019. Finally, the pivotal Phase 3 trial of ADS-5102 in multiple sclerosis patients with walking impairment inroads is enrolling well.

There is strong enthusiasm by both the investigators and coordinators, as evidenced by our screening and enrollment across the majority of 66 U.S sites. As reported previously, we continue to expect full enrollment in second half of 2019.

If the data are sufficiently persuasive, we look forward to initiating a second Phase 3 study and bringing this new indication to market in 2022. Lastly, we remain on track to initiate registration trials for ADS-4101 in 2019.

As Greg led off, we are staying true to our vision to create a world in which time-dependent medicines are the standard of care for the central nervous system disorders. Thank you.

And back to Greg.

Thank you, Rajiv. I continue to be pleased with the progress of the GOCOVRI launch today and with the steps we are taking to drive performance going forward.

I’m also excited by the remarkable durability of GOCOVRI, as shown at the MDS meeting in Hong Kong, as well as our advancing development pipeline Rajiv spoke of. We also have a lot of value to add for patients.

And with our intellectual property portfolio, we believe we have the time and protection to do it. Intellectual property is a pillar of our execution strategy at Adamas, specifically with respect to GOCOVRI and ADS-5102; we are pleased with the continuing validation of the breadth and strength of innovation in our portfolio.

Recently, we defeated an opposition to our diurnal pattern family in Europe. And the U.S.

Patent and Trademark Office allowed a new patent covering the innovation of GOCOVRI’s benefit with respect to OFF with an expiry date of June 2034. Also, while is our policy not to comment on litigation, we remain confident in our ongoing patent enforcement actions.

We have most recently asserted affirmative claims of infringement against OSMOTICA on nine separate patents seeking various forms of relief, including damages. We will continue to aggressively enforce and defend our IP for the benefit of patients and for the benefit of our shareholders.

My thanks to the entire Adamas team for their amazing efforts this quarter. And with that, I’d like to open up the call for questions.

Operator?

Hey, thanks for taking the questions. Strong performance again in the quarter.

Maybe, you can comment a little bit further on some of the issues we’ve heard about regarding persistence, the titration phase, percent of patients that are able to work through that. How prevalent or persevering an issue is it?

And is it something that you think you can improve upon? And then separately, Alf, you reiterated 1% market penetration in 2018, 2% in 2019.

Is this the cadence going forward? Or do you see any reason for the acceleration or penetration beyond or even within 2019?

Thanks.

Josh, it’s Greg. Thank you for your questions.

Let’s start with Rajiv on what we’re seeing with the drop offs.

So, we’re seeing excellent persistence and to be specific, we’re seeing significant majority of persistence at six months, which is really great. Persistence is expectedly lower in the more elderly patients, which is actually consistent with our Phase 3 program and labeling.

We are focused on improving it by educating physicians on appropriate dosing. For example, starting the 68.5 milligram dose in patients who are moderately legally impaired.

Again, all consistent with labeling.

And Alf?

Yes, Josh. So, you remember last year, the 1% framework is what we’ve captured as a reasonable framework for I think of first year penetration.

And that was in reference to the dyskinetic population with 150,000 to 200,000, as you know. We internally tend to think of the one of that range is for the planning, but certainly the entire range is the references scope of the market.

The 2% number that we’ve suggested you for next year; we naturally would hope to beat that. We would talk to beat any number of the kids out there.

So again, we just think that’s a prudent way to be thinking about next year. And I think as Greg described on the call, we’ve been doing understanding certain key learnings from our first nine months and implementing some actions, which we believe will help us get to that benchmark or products beyond.

One more question if I may, it looks like in the third quarter, you’ve now switched to growth driven, much more extensively by scripts per prescriber as opposed to the incremental number of prescribers, which seems to be slowing a little bit. Maybe as you look at the trends throughout the quarter, you can give us a sense of what you expect going forward as the primary driver.

And whether this – either of these growth trajectories are at some kind of a steady state?

Josh, it’s Greg, let me take that on. What we’re seeing in my remarks on the call, it really kind of reflects the sort of specialty, subspecialty nature of this market.

We’re getting very, very strong adoption in the movement disorders we’ve become adopted in with a greater 5% penetrance in that percentage, which means a relatively high volume prescription there. And then if you look back all the way down to the general neurologist, it’s still in a smaller population and in more of a trialing phase.

So with the efforts we’re going to take during the quarter and in next quarter, it really is about aligning sales execution and incentives into those movement disorder centers, the simplification of the messaging and then the educating on the breadth of patients present there and your other message, which was how to properly dose them, we think is what’s going to drive the business forward. And what that’s going to lead to is, we believe greater penetrance in these very large centers and where we have neurologists, who have eligible patients.

It’s a smaller practice and we look forward to seeing that occur as well. But clearly for the next several quarters, the focus is on the larger centers and deepening the prescribing behavior per physician.

Great. Thanks very much.

Thanks, Josh.

Sorry about that. Can you hear me now?

Yes, I can hear now.

All right, thanks. So, just a couple of quick ones.

So first on the payer landscape, any changes that you’ve observed regarding a step edits and anything regarding increasingly onerous prior OFFs that we should be aware of and as penetration deepens, any thoughts on, how the landscape might change. And then secondly, Greg, you’ve commented on, trying to push into less severely diskinetic patients.

Do you get the sense that movement disorder specialists and neurologists in general, have a different view of the risk benefit profile of amantadine and GOCOVRI in less severely diskinetic patients? And maybe, I’ll help us understand how the prescriber or audience thinks about that subgroup?

Thanks.

So let me handle the first one, David. Thank you for the question.

With regards to the payer landscape, we have not seen a change. We continued to be covered through prior authorizations, mix of prior authorization and the medical necessity.

The prescriptions are being filled in a vast majority and they’re being filled quickly. So while we continue to work to improve it, we haven’t seen a change and although that may not predict future performance, we don’t expect anything on the near horizon right now and I think it kind of reflects the value that we’re bringing to patients with GOCOVRI.

With regards to moving earlier in the journey, I’ll let Rajiv comment on what we sort of see as normal practice in patients that a doc is likely to prescribe to Rajiv, you want to handle?

Yes. I think what we’re seeing with the use of GOCOVRI amongst movement disorder neurologists is they are initially trying it in patients, who are more severely diskinetic or have had dyskinesia for a long period of time.

And then based on their experiences in that subpopulation, there is an opening up there, utility GOCOVRI in patients, who had less severe or milder dyskinesia or new onset dyskinesia. So, this is very much what we expected to see amongst the movement disorder community.

And the other thing I would also add, and this was in Greg’s commentary and my commentary is the effect on OFF with GOCOVRI is something that the movement disorder community is very drawn to. And part of what we will also increase the use of GOCOVRI in patients with new onset dyskinesia or mild dyskinesia is the secondary benefit and OFF, which is something that this expert community does not ascribe to other forms of amantadine.

Okay, thanks. And if I may just sneak in a quick additional question on – just on MS gait, is the FDA clearly communicated to you that you have to do a second study?

If I thought there was some ambiguity previously about whether or not you were going to do one. So, I just wanted to clarify what the FDA is telling you in terms of what you need to do to get to a filing.

David, it’s Greg. I think as you know, the communication sponsors have with the FDA, we don’t go in a lot of detail, are always allowed for interpretation once data comes in.

And that was certainly true for the initial approval of GOCOVRI, and we’d expect it to be here. The results of the initial study are compelling.

We will take that back to the FDA and have a conversation. I will point out that the – in terms of the protection and the timeline, we’ve indicated that that product should be expected in your mind to be ready for the market in 2022 and that’s kind of timed as well with the expiration of our orphan exclusivity late in 2024.

Okay, thanks.

Thanks, David.

Hey, thanks guys. So, just a question on the new patient starts.

I just wanted to confirm what I scribbled down here. So, I think you said there were the same quarter-over-quarter, do you mean literally, they’re the same or was there any growth?

So if you could just clarify and then maybe give us some perspective of how much you’re giving away and providing outside of the capture, that you’re giving us, so that we understand maybe what the real demand is even outside of the paid prescriptions. And then lastly, I think Greg, you hit on this, but I’m a little confused.

I mean, you’re basically saying you’re going to be focusing on high prescribers and high prescribing centers and that just seems like an obvious, so you can just kind of backtrack and explain maybe what you were doing before that. That was not an area of focus.

Thank you.

Alf, you want to start with the quarter-over-quarter and then I take prescribers.

Yes, Ken. We’re not wanted to get into sort of the specifics of NRx levels and so on.

But what we’re trying to convey was that internal term, we use generally consistent. So, really, we’re saying that we’re in that very same range quarter-to-quarter.

That was the tone that we were trying to get a general sense that you’re trying to convey. With regard to the question was sort of free drug, I think that was the gist of your question.

And we continue to see a minority of prescriptions, patients coming through the Quick Start program. So, it’s there as part of our armor if you like, but not necessarily, a significant element.

It’s not trivial, but it’s certainly not significant.

And then Ken, I’ll take the last one. Yes.

The notion that you would go to the highest volume, physicians seemed rather straightforward. In the launch period though and I think this is true of everyone and as you begin to collect data over the first nine months, you’re really able to refine what that balance is in your sales execution, your message execution, how that message execution varies by physician type and to the question that was asked earlier, where can you explore the greatest breadth of patients as you go through the launch phase with the general dynamic that doctors are going to start where they’ve got these rather large unmet need populations, who have never had a treatment for dyskinesia and never had a treatment for dyskinesia and OFF.

So, it’s not turning on something that wasn’t already on is refining it and really aligning the incentives of the sales team of the company onto those centers and really allowing people to get to a higher frequency there to spend the time that’s required to make an impact in those environments. So, nothing new on the overall concept, but yes, a shift in how we are directing and incentivizing based upon what we’ve seen over the first three quarters.

Great. Thank you.

Thanks, Dave – Thanks, Ken.

Hi, it’s Ryan for Jason. Thanks for taking the questions.

I had a quick follow-up, I hope on the josh’s and Ken’s questions. I guess it sounds like you’re no longer targeting 6,500 physicians.

Can you tell us how many prescribers you’re targeting in these movement disorder centers and then how many prescribers do you think you need to achieve this 25% to 30% penetration?

That’s a great insight and a great question. So, thank you for that.

What we’re doing right now at this point in the launch is focusing down on a little less than half of that 6,500 right now. We’ve got about 1200 writing and by taking the footprint that we have, which is well positioned around the country, juxtaposed these movement disorder centers and really directing them to spend their time to a greater proportion, increasing the frequency at those difficult to get into centers, which by the way contain multiple prescribing physicians.

We anticipate getting much better overall performance to be able to achieve our goal. Over time, after that beachhead is secured, we will continue to promote, maybe broaden out our promotion to a five-year degree.

But over the next several quarters, our focus is really dedicated on those movement disorder centers at this point.

Okay, great. And you may have just answered the question, but how long do you expect these changes to take the selling efforts and when do you think we’ll probably see the results of those changes?

Thanks.

Yes. I think it’s typical to see when you’re making changes in the normal changes during the course of a quarter-over-quarter, to see a few quarters until you see the impact of it.

But obviously we’re looking at ways of detecting the benefit at a very early stage and continue the process of learning as anyone would and as you would expect us to during the course of a launch.

Okay, thank you.

Hi. Thanks for taking the questions.

I just wanted to understand, won’t physicians be somewhat reluctant to learn about the glutamate pathway or to treat, milder dyskinesia patients given their preconceived notions about, this is just amantadine and we already know how to use it – isn’t it a bit of an uphill battle to educate them on these concepts? That’s question one.

And then the second question is, is do you think you have enough cash to take you through to profitability with this product? Maybe you can comment on that.

Thanks.

So let me tee this up and then throw to Rajiv and have Alf handle the cash question. So, to tee this up over the last few decades, the notion that there’s a glutamate pathology underlying Parkinson’s is something, which is taught arena in med school and yet as we grow in the field, dopaminergic approaches have dominated.

So, Rajiv has been leading this charge here since he’s joined the company. Maybe you can comment, Rajiv, on how you’re approaching this?

I’ll just go back and reiterate what I said in the commentary about in Movement Disorders Society Meeting. There was high interest in the mechanism of dyskinesia and OFF, due in part to the overactive glutamate system.

So that is an example indicating to us that the community of movement disorder neurologists is very much interested in how does – how we do what it does clinically. So that’s point number one and point number two, about GOCOVRI is what I said in our earlier question, they are very drawn not just to the effect on dyskinesia, but they’re equally drawn to the effect in OFF time.

And that’s something that since I have joined arena, has been what puts this medicine in the juxtaposition to other medicine to treat this population at this point in the journey of Parkinson’s disease. I’m not talking about new onset Parkinson’s disease.

I’m talking about patients in Parkinson’s disease that exited, what we call the honeymoon period and now are experiencing dyskinesia and OFF.

And I do think that’s really what the entire clinical program demonstrated and validated. And it’s the source of the curiosity that we’re going to tap into – continue to tap into arena through our disease education efforts.

Alf, on the cash?

Yes. So Irina, really the way we characterize our cash hasn’t changed in the last couple of quarters, where we believe, we’re well capitalized, continue to go GOCOVRI launch to complete the Phase 3 trial in MS walking, it’s ongoing, and similarly finished off the 4101 pivotal study.

So, I think we made total $33 million in cash burn – operating burn in the third quarter is $23 million. So, I think, we believe we are in pretty strong cash position.

One other relating point I would make, just in terms of your modeling, we’re not formally updating our expense guidance for the year, but I think it’s – you can look at the expenses year-to-date and would expect our expenses for the year to be near to the low end of our guidance range, not the higher end.

Okay. And just one follow-up.

I think last quarter; you’ve talked about how physicians are sort of in the middle of like a wait-and-see period and just deciding what to do. Can you comment on how that has changed?

What have those doctors concluded?

I think for the physicians, it’s Greg, for the physicians, who have begun in the larger movement disorder centers, you can see from the numbers that we’ve reported that, they’re doing quite well. It’s not as large of a fraction as we would like at this time, which is why we’re going to continue to focus there.

And the folks, who are in the more general neurology area, do continue to trial. They have a larger space between visits and a larger, therefore space between getting feedback.

And from my earlier comment, we’re not ignoring the importance of getting GOCOVRI into the hands of all 6,500 neurologists overtime, we’re in fact quite thrilled with being a 1200 at this early point in the launch in terms of riders, but we expect that to continue in the general neurology, but in the movement disorder area, it’s a little more of a rapid adoption with larger numbers of patients.

Okay. Thank you.

Hey, good afternoon. Thanks for taking the questions.

So, I’d like to understand just a little bit better. The profile of the movement disorder centers, what percentage of disease suffers are accessed through movement disorder centers do you suppose?

And then the second question, if a patient is being seen through one of these centers, how often are they seeing a neurologist versus other clinicians through the center nurse practitioners in the like? Thanks.

Those are excellent questions. And as you can imagine, they vary center-by-center.

We would have talked about different estimate of the percentage of Parkinson’s patients treated at movement disorder centers, and there’s no exact way to answer that question. But I think a good thoughtful number is in the area of 40% to 60% are treated in those centers.

There are, again, depending on the reference in the math, somewhere between 100 and 200, it’s just sort of – there’s not a stated number that this is exactly what it is. And they do, as you’re neatly pointing out, have a practice, which has a combination of academic department, head neurologist, younger neurologist, who are seeing lots of patients, and assistants, who are covering off on these patients.

The exact treatment pattern as to who’s seeing who, Rajiv, I don’t know, if you want to lay in on, I gave the numbers, but in terms of what it’s like inside?

I think it’s very valuable. You’ll see a typical academic movement disorder center having composed of senior movement disorder neurologists, who have been practicing for many, many years and having an established patient panel, new faculty members that have just joined the practice and are building their practice.

And then you have the allied health professionals, as you point out nurse practitioners or PA. So, it’s really very heterogeneous and very geographical.

And the other key point, I’d make is often many of these movement disorder neurologists, but then also consult with the general neurologists, who provide more of the care in-between the movement disorder clinic follow-ups, which can happen at a cadence of maybe every three to six to nine months depending on the practice and the patient.

And when I – it’s Greg in. So when I referenced the dynamics that we’ve begun to learn, more intensely, most of our learning came from really establishing ourselves in the clinical trial area at some of these movement disorder centers starting in 2010.

But the experience of having our nasus on the ground working each and every day to really understand the local dynamics that Rajiv, just referred to is part of the learnings that’s allowing us now to better target and better deploy our resources.

Thank you.

Well, thank you very much for taking the questions and congratulations on the quarter. I wanted to ask whether you felt at this juncture knowing what you know about the product at this stage of the launch, whether you think the reduction in the number of daily transitions or the long-term effectiveness data represents the most crucial factor in impacting patient retention for GOCOVRI?

I’m going to let Rajiv handle that, we’re smiling, go ahead.

I think it’s both. It’s both and it goes back to persuasiveness.

And I’ll just share with you an anecdote when I was out visiting a movement disorder center recently. The transitioned data allows the movement disorder neurologist to have a communication, a dialogue with their patients, let’s say based on the clinical trial data, this is what was – this was the treatment effect of GOCOVRI during a day.

And ultimately, and you’ve heard Greg say this, feel, function and live; feel, function and live is about the day. So, the transition date is about communicating, translating the clinical trial data of GOCOVRI to a patient.

The long-term data, which is a combination of our controlled trials and our open label trial that’s the evidence that the prescriber needs to say that this medicine GOCOVRI provides durability of effect, because since this is a progressive neurodegenerative disorder, we get this question all the time, is there a durability of effect or is there a waning of effect since this is a symptomatic treatment. And so the fact that we now have pivotal data out to six months, supportive data out to a total of two years, gives the movement disorder neurologist the evidence he or she needs to say that this drug is durable.

So, I closed with how began both are equally important.

Okay. And then with respect to the prior authorization paradigm for the MS patient population, obviously, it’s early days yet, but could you maybe talk about what you’ve experienced so far with the prior authorization paradigm for GOCOVRI and how you think that might compare to the prior authorization paradigm for 5102, if it were to be approved in treatment of walking impairment in MS.

And then I just have two quick questions on 4101, do you have any further granularity on when the 4101 pivotal trial is likely to start within the context of 2019, and if you could elaborate for us on what you expect the principal efficacy endpoints to be and what prior pivotal trial programs in epilepsy might be the most appropriate sort of models for this, what would be the most comparable kind of pivotal trial programs in epilepsy to the 4101 program? Thank you.

Let me take the first two, it’s – we’re obviously a long-time away from bringing areas to 5102 or GOCOVRI to market in MS. So, it really is too early to predict Ram, what if anything will have changed by the time we get to 2022.

We’re happy with the processes, which are in place right now. We’re getting a vast majority of patients on drug in the short period of time through the prior OFF and medical necessity process, but where we’ll end up being in 2022, I just think it’s a little early to detect.

I do – but tell you though, as we look at the data for 5102, and MS, we will be in that position if we continue as we have the GOCOVRI implying in providing a really strong value proposition for all stakeholders, who are involved, so that they see the value of reimbursing and staying on GOCOVRI. And your second question, I’m not going to comment further on the timing of 4101.

We’ll give an update, in the first quarter on how that’s coming and finally, Rajiv analog in terms of endpoints for…

I think for endpoints in the 4101 program, I would look to other approved, adjunctive antiepileptics, that’s a framework we’re looking at as we think about what the registration program would look like. So, there are many examples to look at on how adjunctive antiepileptics are developed, and what efficacy endpoints are looked at, which come down to looking at a measure of seizure frequency.

Great. Thank you very much.

And the other point I want to just make back to MS, which we mentioned earlier was, in the ongoing Phase 3 trial for MS, we’re going to capture – we’re going to collect data on the effect of 5102, both in patients who are naïve to dalfampridine as well as in patients, who were on dalfampridine in the past. So, our thesis is, we’ll be able to generate data in a wider population including dalfampridine failures, because based on their own registration program and what we pass it, we think to be subject to Phase 3 confirmation, we’ll have a larger treatment effect in a broader population.

Great. That’s very helpful.

Thank you very much.

Thanks, Ram.

Hey, thanks. Sorry about that earlier.

Sorry for cutting you off, Serge.

No, no worries. So I just have a question.

Do you expect any increase in the formulary coverage starting next year? And do you expect the launch of OSMOLEX to affect your future coverage in 2019 and going forward?

Thanks.

Thanks for the question. We don’t really expect any change in the formulary coverage.

As you know, we’re not a formally covered, but we are reimbursed and the majority of prescriptions are we getting reimbursed in a really good period of time. We have heard a bit about OSMOLEX coming to the market.

That product has a very different value proposition being once daily in the morning equivalent version of amantadine IR. I think it will be – and it has a separate indication, it is supported only by pharmacokinetic data and not by any efficacy data since as you recall the original label for Symmetrel does not contain a significant data package to promote to.

And so I think it will be largely independent from us in terms of how it ends up being reimbursed and what its challenges will be and whether or not it gets folded into something that physicians are encouraged to try as some plans have done with amantadine IR, I think remains to be seen. But again, we are – we’ve been facing that market reality since, well before we launched the product and are pleased with how that is playing out right now in terms of any kind of a prior attestation of use of amantadine IR.

At bottom line and it goes back to an earlier question on the call, this is a brand-new effect of a product is a time-dependent interaction with the glutamate pathway as opposed to other approaches that have been taken and this is really durable benefits that Rajiv just talked about in dyskinesia and OFF, this widening of the window to render all dopaminergic therapy is more flexible, is a really remarkable accomplishment and a detectable effect in the lives of these patients in these physicians. So, we’re going to get them eventually as my view, because the value is there.

Thank you.

Thanks, Serge.

So, I thank you for all of your time today. We look forward to seeing you at an investor conference this fall, and getting closer to the holidays and we look forward to updating you on our continued progress on our next call in February.

Thank you very much.