Alnylam Pharmaceuticals, Inc.

Alnylam Pharmaceuticals, Inc.

ALNY
Alnylam Pharmaceuticals, Inc.US flagNASDAQ Global Select
249.59
USD
+3.08
- -
33.40BMarket Cap
2013 Y
2014 Y
2015 Y
2016 Y
2017 Y
2018 Y
2019 Y
2020 Y
2021 Y
2022 Y
2023 Y
2024 Y
2025 Y
TTM
Revenue per Share
0.77
0.68
0.49
0.55
0.99
0.74
2.01
4.29
7.13
8.53
14.64
17.61
28.35
36.25
Basic EPS, GAAP
-1.45
-4.85
-3.45
-4.79
-5.42
-7.57
-8.11
-7.46
-7.2
-9.3
-3.52
-2.18
2.39
6.1
Free Cash Flow per Basic Share
-1.18
-2.35
-2.41
-4.35
-5.38
-6.85
-3.83
-5.96
-6.06
-5.04
0.34
-0.33
3.55
6.19
Dividend per Share
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
Book Value per Share
4.24
12.13
14.86
10.71
17.72
12.87
12.82
8.73
4.89
-1.28
-1.75
0.52
5.96
10.13
Tangible Book Value per Share
4.24
12.13
14.86
10.71
17.72
12.87
12.82
8.73
4.89
-1.28
-1.75
0.52
5.96
10.13
Basic Weighted Avg Shares
62
74
84
86
91
101
109
115
118
122
125
128
131
133
Sales/Revenue/Turnover
47
51
41
47
90
75
220
493
844
1,037
1,828
2,248
3,714
4,804
Operating Margin (%)
-197.05
-364.34
-720.27
-900.33
-556.2
-1,087.56
-427.5
-168.09
-83.93
-75.68
-15.43
-7.87
13.51
20.81
Depreciation Expense
10
12
19
15
12
15
54
74
90
44
54
57
56
55
Net Income, GAAP
-89
-360
-290
-410
-491
-761
-886
-858
-853
-1,131
-440
-278
314
808
Effective Tax Rate (%)
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
2.91
14.55
Profit Margin (%)
-189.17
-712.79
-705.83
-869.63
-545.95
-1,016.58
-403.24
-174.15
-101.01
-109.04
-24.08
-12.37
8.45
16.82
Working Capital
200
651
1,043
540
1,620
1,021
1,363
2,030
2,113
1,924
2,015
2,109
2,584
3,108
LT Debt
- -
- -
- -
150
30
30
276
484
957
1,278
1,264
1,254
1,233
1,221
Total Equity
270
936
1,265
920
1,766
1,302
1,439
1,016
588
-158
-221
67
789
1,354
Return on Invested Capital (%)
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
28.39
- -
Return on Capital (%)
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
32.59
80.11
Return on Common Equity (%)
-44.13
-59.74
-26.36
-37.54
-36.54
-49.63
-64.66
-69.92
-106.31
- -
- -
- -
73.28
100.7

Capital Structure

FRC

•

in mil. unless spec.
Dec'25
Mar'26
Jun'26
ST Debt
46
46
46
LT Borrowings
1,008
1,009
1,011
LT Finance Leases
225
218
210
Preferred Equity and Hybrid Capital
- -
- -
- -
Shares Outstanding
132
133
134
Market Capitalization
52,639
44,153
40,258

Working Capital

FRC

•

in mil. unless spec.
Dec'25
Mar'26
Jun'26
Total Current Assets
4,051
4,219
4,620
Cash, Cash Equivalents & STI
2,908
3,009
3,308
Accounts Receivable, Net
778
884
913
Inventories
83
84
97
Total Current Liabilities
1,466
1,349
1,513
Payables & Accruals
939
1,073
1,204
ST Debt
46
46
46
Deferred Revenue
5
3
4

Growth Rates

FRC

•

in mil. unless spec.

(avg. rate of change)

10 years
5 years
1 year
Total Equity
83.59%
163.27%
1,076.33%
Free Cash Flow
-132.99%
-302.18%
-1,192.73%
Net Income, GAAP
-14.93%
-55.74%
-212.79%
Sales/Revenue/Turnover
66.49%
51.72%
65.19%
Total Cash Common Dividend
- -
- -
- -

Quarterly Revenue

FRC

•

in mil. unless spec.

Year

Q1
Q2
Q3
Q4
FY
2024
494
660
501
593
2,248
2025
594
774
1,249
1,097
3,714
2026
1,167
1,291
- -
- -
- -

Quarterly Earnings Per Share

FRC

•

in mil. unless spec.

Year

Q1
Q2
Q3
Q4
FY
2024
-0.52
-0.13
-0.87
- -
-2.18
2025
-0.14
-0.55
1.91
1.41
2.39
2026
1.55
1.23
- -
- -
- -

Quarterly Dividends Per Share

FRC

•

in mil. unless spec.

Year

Q1
Q2
Q3
Q4
FY
2024
- -
- -
- -
- -
- -
2025
- -
- -
- -
- -
- -
2026
- -
- -
- -
- -
- -

Company Description

CEO
Yvonne L. Greenstreet
Full Time Employees
2,500
Sector
Healthcare
Industry
Biotechnology
Address
675 West Kendall Street Cambridge MA United States of America 02142
IPO Date
Jun 1, 2004
Business
Alnylam Pharmaceuticals, Inc. (ALNY) develops and commercializes RNA interference (RNAi) therapeutics targeting genetically defined diseases; core products include ONPATTRO (patisiran) for hereditary transthyretin-mediated (hATTR) amyloidosis with polyneuropathy, AMVUTTRA (vutrisiran) for ATTR amyloidosis with polyneuropathy or cardiomyopathy, GIVLAARI (givosiran) for acute hepatic porphyria, and OXLUMO (lumasiran) for primary hyperoxaluria type 1; the company also advances partnered programs such as Leqvio (inclisiran) for hypercholesterolemia marketed by Novartis. Founded in 2002 and headquartered in Cambridge, Massachusetts, Alnylam operates globally with key facilities in the US, Europe (including France, Italy, Netherlands, Sweden, Switzerland, and the UK), and Japan. The company maintains strategic collaborations with Roche on zilebesiran for hypertension, Regeneron for CNS diseases, Sanofi on fitusiran for hemophilia, and others including Novartis and Agios Pharmaceuticals. Recent developments encompass expansion of AMVUTTRA into ATTR cardiomyopathy with strong launch uptake and upgraded 2025 revenue guidance, initiation of a Phase 1 trial for ALN-4324 targeting GRB14 for type 2 diabetes, and Agios' IND clearance for AG-236 (ALN-TMP) in polycythemia vera; Alnylam joined the Alliance for Genomic Discovery in 2025 to leverage datasets for gene-silencing medicines and extended its partnership with Medison Pharma into LATAM and APAC markets. Pipeline advancements feature nucresiran for ATTR amyloidosis, mivelsiran for Alzheimer's disease and cerebral amyloid angiopathy, and positive Phase 3 data for zilebesiran. These efforts support Alnylam's transition to profitability with 2024 net product revenues exceeding $1.3 billion across rare and cardiometabolic indications.

Company News

  • Alnylam Pharmaceuticals (NASDAQ:ALNY) & Tango Therapeutics (NASDAQ:TNGX) Head to Head Survey

  • Alnylam Pharmaceuticals, Inc. (NASDAQ:ALNY) Receives Average Rating of “Moderate Buy” from Analysts

  • 4 Alzheimer's Drug Stocks to Watch on World Alzheimer's Day

  • Alnylam Highlights AMVUTTRA Momentum, Resets 2026 TTR Revenue Outlook

  • Alnylam’s Zilebesiran Targets Twice-Yearly Blood Pressure Control in ZENITH Trial

  • Alnylam Highlights AMVUTTRA Momentum, Resets 2026 TTR Revenue Outlook

  • Alnylam's Zilebesiran Targets Twice-Yearly Blood Pressure Control in ZENITH Trial

  • Alnylam Pharmaceuticals, Inc. (ALNY) Discusses Zilebesiran and the Potential of RNAi Therapeutics for Continuous Blood Pressure Control Transcript

  • Alnylam's Sell-Off Looks Ugly -- but Wall Street Still Sees a Much Brighter Picture

  • Arizona State Retirement System Boosts Stock Position in Alnylam Pharmaceuticals, Inc. $ALNY

  • Concurrent Investment Advisors LLC Acquires 6,576 Shares of Alnylam Pharmaceuticals, Inc. $ALNY

  • Alnylam Pharmaceuticals, Inc. (ALNY) Presents at Wells Fargo 21st Annual Healthcare Conference Transcript

  • Alnylam to Webcast Presentations at Upcoming September Investor Conferences

  • 4 Rare Disease Drugmakers With Strong Long-Term Growth Prospects

  • Alnylam Pharmaceuticals, Inc. (NASDAQ:ALNY) Receives $386.14 Consensus Target Price from Analysts

  • Alnylam Presents New Data at ESC Congress 2026 Reinforcing Strength in RNAi-Powered TTR Silencing Across ATTR-CM Patient Populations and Treatment Settings

  • Alnylam Presents New Data at ESC Congress 2026 Reinforcing Strength in RNAi-Powered TTR Silencing Across ATTR-CM Patient Populations and Treatment Settings

  • ALNY INVESTOR ALERT: Kirby McInerney LLP Investigates Potential Claims Involving Alnylam Pharmaceuticals, Inc.

  • Alnylam to Present New Data Reinforcing Strength in RNAi-Powered TTR Silencing and Continued Progress in Hypertension at ESC Congress 2026

  • (NASDAQ: ALNY) Investor Alert: Kessler Topaz Meltzer & Check, LLP Encourages Alnylam Pharmaceuticals, Inc. Investors to Contact the Firm