Castle Biosciences, Inc.

Castle Biosciences, Inc.

CSTL
Castle Biosciences, Inc.US flagNASDAQ Global Market
20.70
USD
-0.31
- -
627.83MMarket Cap
2017 Y
2018 Y
2019 Y
2020 Y
2021 Y
2022 Y
2023 Y
2024 Y
2025 Y
TTM
Revenue per Share
1.41
2.14
6.04
3.31
3.74
5.26
8.2
11.96
11.88
11.6
Basic EPS, GAAP
-1.56
-0.93
0.36
-0.54
-1.24
-2.58
-2.14
0.66
-0.83
-0.44
Free Cash Flow per Basic Share
-1.3
-1.18
0.71
0.27
-0.89
-1.81
-0.72
1.32
0.98
0.15
Dividend per Share
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
Book Value per Share
-5.22
-5.4
-6.08
-3.3
-3.73
-6.17
-8.15
-7.2
-7.74
-8.15
Tangible Book Value per Share
-5.15
-5.31
9.92
21.96
12.84
10.47
10.22
12.59
12.81
12.42
Basic Weighted Avg Shares
10
11
9
19
25
26
27
28
29
29
Sales/Revenue/Turnover
14
23
52
63
94
137
220
332
344
340
Operating Margin (%)
-79.25
-16.83
14.13
-10.44
-42.6
-66.51
-30.93
2.61
-12.44
-9.79
Depreciation Expense
- -
- -
- -
- -
3
11
12
16
41
15
Net Income, GAAP
-12
-6
5
-10
-31
-67
-57
18
-24
-13
Effective Tax Rate (%)
- -
- -
1.35
- -
- -
- -
- -
15.39
- -
- -
Profit Margin (%)
-89.93
-27.94
10.17
-16.42
-33.26
-48.99
-26.15
5.49
-7.02
-3.78
Working Capital
1
11
101
409
329
256
248
311
292
280
LT Debt
18
24
19
- -
7
12
14
24
35
34
Total Equity
-14
-10
85
416
412
399
391
456
471
461
Return on Invested Capital (%)
- -
- -
11.59
- -
- -
- -
- -
1.65
- -
- -
Return on Capital (%)
- -
- -
-144.3
- -
- -
- -
- -
-9.94
- -
- -
Return on Common Equity (%)
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -

Capital Structure

FRC

in mil. unless spec.
Sep'25
Dec'25
Mar'26
ST Debt
1
2
3
LT Borrowings
10
10
8
LT Finance Leases
26
26
25
Preferred Equity and Hybrid Capital
- -
- -
- -
Shares Outstanding
29
30
30
Market Capitalization
653
1,127
719

Working Capital

FRC

in mil. unless spec.
Sep'25
Dec'25
Mar'26
Total Current Assets
358
361
329
Cash, Cash Equivalents & STI
288
300
262
Accounts Receivable, Net
49
43
42
Inventories
9
10
10
Total Current Liabilities
55
69
49
Payables & Accruals
19
25
22
ST Debt
1
2
3
Deferred Revenue
- -
- -
- -

Growth Rates

FRC

in mil. unless spec.

(avg. rate of change)

10 years
5 years
1 year
Total Equity
- -
2.76%
3.3%
Free Cash Flow
- -
-160.09%
-22.48%
Net Income, GAAP
- -
-11.95%
-232.41%
Sales/Revenue/Turnover
- -
42.19%
3.66%
Total Cash Common Dividend
- -
- -
- -

Quarterly Revenue

FRC

in mil. unless spec.

Year

Q1
Q2
Q3
Q4
FY
2024
73
87
86
86
332
2025
88
86
83
87
344
2026
84
- -
- -
- -
- -

Quarterly Earnings Per Share

FRC

in mil. unless spec.

Year

Q1
Q2
Q3
Q4
FY
2024
-0.09
0.32
0.08
0.34
0.66
2025
-0.9
0.16
-0.02
-0.08
-0.83
2026
-0.49
- -
- -
- -
- -

Quarterly Dividends Per Share

FRC

in mil. unless spec.

Year

Q1
Q2
Q3
Q4
FY
2024
- -
- -
- -
- -
- -
2025
- -
- -
- -
- -
- -
2026
- -
- -
- -
- -
- -

Company Description

MCPAPIChat
CEO
Derek J. Maetzold
Full Time Employees
784
Sector
Healthcare
Industry
Medical - Diagnostics & Research
Address
505 South Friendswood Drive Friendswood TX United States of America 77546
IPO Date
Jul 25, 2019
Business
Castle Biosciences, Inc. (Nasdaq: CSTL) develops and commercializes molecular diagnostic tests that guide patient care for dermatologic cancers, Barrett's esophagus, uveal melanoma, and related conditions; its core portfolio includes DecisionDx-Melanoma, a 31-gene expression profile (GEP) test predicting metastasis risk, sentinel lymph node positivity, and recurrence in invasive cutaneous melanoma; TissueCypher, a spatial-omics risk stratification test predicting progression to high-grade dysplasia or esophageal cancer in Barrett's esophagus patients with non-dysplastic, indefinite, or low-grade dysplasia; DecisionDx-SCC, a 40-GEP test assessing metastasis risk, adjuvant radiation therapy benefit, and local recurrence in high-risk cutaneous squamous cell carcinoma; MyPath Melanoma, a diagnostic GEP test aiding differentiation of melanocytic lesions; DecisionDx-UM, a GEP test with PRAME refinement predicting metastasis in uveal melanoma; and AdvanceAD-Tx, a 487-GEP test guiding systemic treatment selection for moderate-to-severe atopic dermatitis patients aged 12 and older. The company, founded in 2008 and headquartered in Friendswood, Texas, operates laboratories in Phoenix, Arizona, and Pittsburgh, Pennsylvania, serving clinicians in dermatology, gastroenterology, and oncology primarily in the United States. Recent developments include the May 2025 acquisition of Capsulomics, Inc. (d/b/a Previse), adding methylation-based technology to enhance gastrointestinal offerings and enable multiomics approaches for Barrett's esophagus and non-endoscopic sampling; a June 2025 collaboration and license agreement with SciBase Holding AB leveraging electrical impedance spectroscopy for an atopic dermatitis flare prediction test; discontinuation of the IDgenetix pharmacogenomic test for mental health conditions in May 2025; FDA Breakthrough Device designation for DecisionDx-Melanoma in July 2025; and the launch of AdvanceAD-Tx to address biologic treatment decisions in atopic dermatitis.

Company News

MCPAPIChat
  • First Patient Enrolled in New Study Assessing early prediction of flares in Atopic Dermatitis by Castle Biosciences in Collaboration with SciBase

  • Castle Biosciences to Present at the 2026 Jefferies Global Healthcare Conference

  • Castle Biosciences' AdvanceAD-Tx™ Test Receives 2026 MedTech Breakthrough Award for Genomics Innovation

  • Castle Biosciences, Inc. (CSTL) Q1 2026 Earnings Call Transcript

  • Castle Biosciences, Inc. (CSTL) Reports Q1 Loss, Beats Revenue Estimates

  • Castle Biosciences Reports First Quarter 2026 Results

  • Wall Street Analysts Predict an 85.15% Upside in Castle Biosciences (CSTL): Here's What You Should Know

  • Castle Biosciences Supports Nationwide Patient Advocacy and Screening Initiatives to Celebrate Skin Cancer Awareness Month

  • New Data at DDW 2026 Show TissueCypher® Testing Improves Risk Stratification and Drives Risk-Aligned Management in Barrett's Esophagus

  • Castle Biosciences to Present New Data Demonstrating DecisionDx®-Melanoma's Ability to Identify Patients with Greater Risk of Recurrence and Poor Outcomes Within Early-Stage Melanoma at EADO and ACMS

  • Castle Biosciences to Release First Quarter 2026 Financial Results and Host Webcast on Wednesday, May 6, 2026

  • Castle Biosciences Earns 2026 USA TODAY Top Workplaces Award for Fifth Consecutive Year

  • Castle Biosciences: Buying The Remaining DecisionDx-Melanoma Upside

  • Castle Biosciences' DecisionDx®-Melanoma Test Significantly Improves Risk Prediction Within AJCC Stages to Support Personalized, Risk-Aligned Management of Cutaneous Melanoma, Data to Be Presented at AAD 2026

  • Castle Biosciences, Inc. (CSTL) Discusses Clinical Utility and Evidence Supporting DecisionDx Melanoma Test and DECIDE Study Transcript

  • Castle Biosciences, Inc. (NASDAQ:CSTL) Receives Consensus Recommendation of “Moderate Buy” from Brokerages

  • Prospective, Multi-center Study Published in Future Oncology Demonstrates DecisionDx®-Melanoma's i31-SLNB Result Outperforms Staging Criteria in Identifying Patients with Cutaneous Melanoma Below the 5% NCCN Threshold for Forgoing SLNB

  • DecisionDx®-Melanoma's i31-SLNB: Report from the Largest Prospective Multicenter Study to Date Confirms 2.6% Nodal Positivity in Patients Predicted to Have Less Than 5% Risk

  • Castle Biosciences to Present Data at SSO 2026 on DecisionDx®-Melanoma's i31-SLNB, Identifying T1b–T2a Melanoma Patients Who May Safely Avoid SLNB

  • Castle Biosciences Announces Grand Opening of New Corporate Headquarters in Friendswood, Texas