Silence Therapeutics plc

Silence Therapeutics plc

SLN
Silence Therapeutics plcUS flagNASDAQ Global Market
6.69
USD
+0.01
- -
316.00MMarket Cap
2013 Y
2014 Y
2015 Y
2016 Y
2017 Y
2018 Y
2019 Y
2020 Y
2021 Y
2022 Y
2023 Y
2024 Y
2025 Y
TTM
Revenue per Share
0.01
- -
- -
0.04
- -
- -
0.01
0.27
0.57
0.67
0.85
0.94
0.01
0.02
Basic EPS, GAAP
-1.01
-1.03
-0.46
-0.45
-0.09
-1
-1.03
-1.63
-1.79
-1.56
-1.46
-0.98
-1.88
-1.59
Free Cash Flow per Basic Share
-0.78
-0.91
-0.63
-0.56
-0.57
-0.92
0.09
-0.56
0.25
-1.79
-1.33
-1.47
-1.32
-1.39
Dividend per Share
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
Book Value per Share
-10.08
-9.29
-7.35
-5.96
-6.55
-7.05
-7.75
-9
-9.94
-9.69
-11.41
-10.03
-11.69
-12.01
Tangible Book Value per Share
2.23
1.91
3.73
2.46
2.57
1.45
0.69
0.05
0.04
0.52
0.31
2.69
1.09
0.82
Basic Weighted Avg Shares
15
17
21
23
23
23
25
27
30
32
37
46
47
47
Sales/Revenue/Turnover
- -
- -
- -
1
- -
- -
- -
7
17
22
32
43
1
1
Operating Margin (%)
-7,753.85
-80,846.67
- -
-1,546.23
-89,943.75
- -
-9,317.21
-654.26
-369.02
-281.87
-203.47
-146.38
-16,055.99
-9,187.25
Depreciation Expense
- -
1
- -
- -
1
1
1
1
1
1
1
1
1
1
Net Income, GAAP
-15
-17
-10
-10
-2
-23
-26
-44
-53
-50
-54
-45
-89
-75
Effective Tax Rate (%)
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
Profit Margin (%)
-7,694.02
-73,920
- -
-1,096.1
-10,112.5
- -
-8,025.41
-594.03
-317.44
-232.44
-171.37
-104.74
-15,851.88
-8,943.86
Working Capital
32
31
78
50
58
33
36
69
96
90
81
171
105
92
LT Debt
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
Total Equity
45
43
90
67
71
44
27
12
12
27
22
134
62
49
Return on Invested Capital (%)
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
Return on Capital (%)
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
Return on Common Equity (%)
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -
- -

Capital Structure

FRC

in mil. unless spec.
Sep'25
Dec'25
Mar'26
ST Debt
- -
- -
- -
LT Borrowings
- -
- -
- -
LT Finance Leases
- -
- -
- -
Preferred Equity and Hybrid Capital
- -
- -
- -
Shares Outstanding
142
142
142
Market Capitalization
182
213
188

Working Capital

FRC

in mil. unless spec.
Sep'25
Dec'25
Mar'26
Total Current Assets
134
119
103
Cash, Cash Equivalents & STI
102
85
70
Accounts Receivable, Net
- -
- -
- -
Inventories
- -
- -
- -
Total Current Liabilities
17
14
10
Payables & Accruals
17
10
10
ST Debt
- -
- -
- -
Deferred Revenue
- -
- -
- -

Growth Rates

FRC

in mil. unless spec.

(avg. rate of change)

10 years
5 years
1 year
Total Equity
41.36%
112.71%
-53.51%
Free Cash Flow
-184.57%
-202.58%
-8.14%
Net Income, GAAP
107.93%
20.28%
95.57%
Sales/Revenue/Turnover
- -
27.55%
-98.71%
Total Cash Common Dividend
- -
- -
- -

Quarterly Revenue

FRC

in mil. unless spec.

Year

Q1
Q2
Q3
Q4
FY
2024
16
1
1
24
43
2025
- -
- -
- -
- -
1
2026
- -
- -
- -
- -
- -

Quarterly Earnings Per Share

FRC

in mil. unless spec.

Year

Q1
Q2
Q3
Q4
FY
2024
-0.05
-0.42
-0.76
- -
-0.98
2025
-0.6
-0.58
-0.44
- -
-1.88
2026
-0.32
- -
- -
- -
- -

Quarterly Dividends Per Share

FRC

in mil. unless spec.

Year

Q1
Q2
Q3
Q4
FY
2024
- -
- -
- -
- -
- -
2025
- -
- -
- -
- -
- -
2026
- -
- -
- -
- -
- -

Company Description

MCPAPIChat
CEO
Iain Gladstone Ross
Full Time Employees
116
Sector
Healthcare
Industry
Biotechnology
Address
72 Hammersmith Road London United Kingdom W14 8TH
IPO Date
Sep 8, 2020
Business
Silence Therapeutics plc (Nasdaq: SLN), founded in 1994 and headquartered in Hammersmith, London, with additional offices in Hoboken, New Jersey, USA, and Berlin, Germany, develops proprietary short interfering RNA (siRNA) therapeutics utilizing its mRNAi GOLD™ platform to silence disease-causing genes in the liver for the treatment of rare and cardiovascular diseases. The company advances a wholly owned clinical pipeline including divesiran (SLN124), an siRNA targeting TMPRSS6 for hematological disorders such as beta-thalassemia and myelodysplastic syndromes; zerlasiran (formerly SLN360), an siRNA designed to reduce elevated lipoprotein(a) levels associated with cardiovascular risk, which demonstrated up to 99% reduction in Phase 1 studies lasting 90 days post-dosing; and other candidates like SLN-312, SLN-548 targeting rare diseases. It also licenses siRNA product candidates through partnerships, notably a collaboration with AstraZeneca featuring an ongoing Phase 1 study of SLN312 in an undisclosed indication, alongside prior agreements with Mallinckrodt Pharmaceuticals and Hansoh Pharma. Recent developments encompass pipeline progression with positive clinical data for zerlasiran reported in November 2023, quarterly financial updates through 2025 showing cash reserves exceeding $114 million to support operations into 2028, and strategic focus on high-unmet-need areas in hematology, cardiovascular disease, and rare disorders. Silence Therapeutics operates globally, partnering with pharmaceutical companies to expand its RNAi technology applications across therapeutic areas.

Company News

MCPAPIChat
  • Silence Therapeutics Stock Rises On Positive Blood Cancer Drug Data

  • Silence Therapeutics Highlights Follow-Up Data at EHA 2026 Demonstrating Durable Efficacy and Potential Best-in-Class Profile for Divesiran in Polycythemia Vera

  • Silence Therapeutics Highlights Follow-Up Data at EHA 2026 Demonstrating Durable Efficacy and Potential Best-in-Class Profile for Divesiran in Polycythemia Vera

  • Silence Therapeutics to Participate in Jefferies Global Healthcare Conference

  • Silence Therapeutics to Participate in H.C. Wainwright BioConnect Investor Conference

  • Silence Therapeutics Highlights Recent Business Achievements and Reports First Quarter 2026 Financial Results

  • Silence Therapeutics (SLN) Soars 19.0%: Is Further Upside Left in the Stock?

  • Silence Therapeutics PLC Sponsored ADR (NASDAQ:SLN) Given Average Recommendation of “Moderate Buy” by Brokerages

  • Silence Therapeutics (NASDAQ:SLN) versus Avalo Therapeutics (NASDAQ:AVTX) Head-To-Head Comparison

  • Wall Street Analysts See a 467.47% Upside in Silence Therapeutics (SLN): Can the Stock Really Move This High?

  • Silence Therapeutics Highlights Recent Business Achievements and Reports Fourth Quarter and Full Year 2025 Financial Results

  • Silence Therapeutics PLC Sponsored ADR (NASDAQ:SLN) Receives Consensus Recommendation of “Hold” from Brokerages

  • Silence Therapeutics Announces Leadership Changes

  • Silence Therapeutics: Divesiran Targets High-Burden PV

  • Silence Therapeutics Reports Third Quarter 2025 Financial Results and Recent Business Highlights

  • Tonix Pharmaceuticals (NASDAQ:TNXP) versus Silence Therapeutics (NASDAQ:SLN) Critical Survey

  • Silence Therapeutics Completes Enrollment in SANRECO Phase 2 Study of Divesiran for Polycythemia Vera (PV)

  • Silence Therapeutics Plc (SLN) Presents At Morgan Stanley 23rd Annual Global Healthcare Conference Transcript

  • Silence Therapeutics Reports Second Quarter 2025 Financial Results and Recent Business Highlights

  • Silence Therapeutics Presents Additional Phase 1 Data Highlighting Promise of Divesiran as the Potential First-in-Class siRNA Treatment for Polycythemia Vera